Natural Lavender Essential Oil

Lavender Essential Oil for Aromatherapy you’ve ever browsed the scented candle or air freshener aisle, chances are that you’ve seen lavender scents. But did you know that this perennial plant also has medicinal properties? “The fragrance of lavender comes from the oils in it and may have a number of benefits, including being calming,” says integrative medicine specialist Yufang Lin, MD. “You can use it topically in your hands or in a diffuser in the home, and you can also take it orally.”

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Lin says that a few drops of lavender oil in a bath can help relieve stress and relax the muscles. You can also add a few drops of lavender oil to a moisturizer to calm skin and reduce redness. If you’re a fan of DIY beauty products, you can make your own lavender oil by infusing dried lavender buds into a carrier oil like coconut or olive. After a few weeks, you can strain the mixture and store it in a dark glass bottle.

When applying lavender oil to the skin, always dilute it with a carrier oil like jojoba or fractionated coconut oil to prevent irritation. Lin recommends using only a few drops of the oil at a time and avoiding it on sensitive areas like your face. You should also avoid ingesting it, as it can cause nausea and vomiting. If you do experience any negative symptoms, contact a medical professional immediately.…

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The adenomatous polyposis coli tumor suppressor (APC) protein downregulates the oncogenic b-catenin in the Xenopus Wnt-1 signaling pathway. Mutations of APC that eliminate this function lead to sporadic and familial colon cancer. The APC protein is regulated in part by its binding to b-catenin and GSK3b, two proteins that bind directly to the APC phosphorylation sites. The b-catenin binding site within APC is located in the region that is deleted by cancer-associated APC mutations. We have shown that the human Axin protein binds directly to both b-catenin and GSK3b in vitro, and that endogenous hAxin coexists with these proteins in cells. URL https://www.bosterbio.com/anti-apc2-antibody-a06153-boster.html

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Yeast two-hybrid and immunoprecipitation assays demonstrate that Axin interacts with both the central domain of APC (amino acids 1034-2130) and the carboxy-terminal fragment, designated APC3, which contains the regulator of G-protein signaling domain (RGS). Deletion of amino acid 9-320 of hAxin, which contains the RGS domain, eliminated binding to APC2, but not to b-catenin or GSK3b. Moreover, immunoprecipitation of hAxin from SW480 and HCT116 colorectal cancer cell lines cotransfected with one plasmid encoding the indicated APC fragment fused to the GAL4 DNA-binding domain and the other encoding a Myc epitope tag, reveals that the endogenous b-catenin-Axin interaction is mediated by the Axin RGS domain.

In a GSK3b assay, hAxin dramatically enhanced the phosphorylation of APC25 when present in the reaction. This enhancement was not observed in the absence of GSK3b or when hAxin was replaced with a GST-hAxin construct that lacks the APC-binding domain. Moreover, overexpression of hAxin in SW480 cells dramatically decreased the levels of b-catenin in the cytoplasm.

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